JakeSmashed95 said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Pushing back on JakeSmashed95 here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

That is the short version; the long version is somebody else's post.

JakeSmashed95 said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

JakeSmashed95 said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Thank you for spelling out the reasoning rather than just the conclusion.

From the other side of the consultation, briefly. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

SarahChen_PharmD said:

If two explanations both fit, the useful question is which one predicts something the other does not.

This matches mine closely enough to be worth saying so out loud.