From the other side of the consultation, briefly. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.
Worth separating that from fatigue, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
EndoResFellow said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Same position here, arrived at the long way round. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.
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View ResultsEndoResFellow said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Adding the part of the answer the thread has not reached. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.