DeniseRN_TPA said:The liver data is among the strongest non-weight findings in the class.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
marcus_mpls said:Steady state is the thing most people miss.
That reframing is the part I needed. I will report back once I have actually tried it.
DeniseRN_TPA said:The liver data is among the strongest non-weight findings in the class.
Pushing back on DeniseRN_TPA here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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