🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseMASH biomarker panel — 6 month update

MASH biomarker panel — 6 month update

JenPlateau Thu, Mar 19, 2026 at 6:02 PM 8 replies 800 viewsPage 1 of 2
JenPlateau
Member
234
890
Nov 2024
Missouri
Mar 19, 2026 at 6:02 PM#1

My prescriber ordered three tests and this board recommends about twenty, and I would like to know which of those two lists is right.

Post reference ranges alongside numbers when you share them. Units differ by country — glucose and lipids especially — and half the confusion in these threads is unit mismatch rather than disagreement.

What I am after is what actually belongs on a baseline panel, as opposed to the enormous list that gets pasted around here.

Not looking for reassurance. Looking for the part I have got wrong.

42 12HPLC_Greg, LibrarianMeg, bri_stats and 39 others
Reply Quote Save Share Report
Dr.PeteFamMed
Senior Member
2,012
9,234
Jan 2024
Minneapolis, MN
Mar 19, 2026 at 7:56 PM#2

Short answer first, then the reasoning. The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value. One out-of-range result in isolation generates anxiety and unnecessary tests; the same result next to the trend and the rest of the panel usually generates a shrug.

41 11tommy_boulder, hyun_seoul, jim_asheville and 38 others
Reply Quote Save Share Report
DeniseRN_TPA
Member
345
1,567
Aug 2024
Tampa, FL
Mar 19, 2026 at 9:50 PM#3
Dr.PeteFamMed said:
The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value.

Dr.PeteFamMed has the substance of this right. The condition it depends on is worth stating. One addition: if the lab changes analytical platform between your draws, the comparison breaks and nobody tells you. It is worth asking when a value moves inexplicably.

40 10tommy_boulder, hyun_seoul, jim_asheville and 37 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
chris_chi24
Member
389
1,678
Sep 2024
Chicago, IL
Mar 19, 2026 at 11:44 PM#4
JenPlateau said:
My prescriber ordered three tests and this board recommends about twenty, and I would like to know which of those two lists is right.

This matches mine closely enough to be worth saying so. Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c becomes informative again, since it reflects about three months of glycaemia. After the first year, and once doses are stable, annual is reasonable unless something specific is being followed.

39 9PurityPaulOR, MaxMetOK, MounjBrad and 36 others
Reply Quote Save Share Report
Dr.ObesityMed
VIP Member
3,456
19,234
Nov 2023
Denver, CO
Online
Mar 20, 2026 at 10:58 AM#5

Adding the clinical framing, because it changes how the question reads.

PSA: get baseline labs BEFORE starting baseline bloodwork therapy. You need a "before" picture to measure progress. My recommended pre-treatment panel:

  1. CMP + A1C + fasting insulin
  2. Complete lipid panel with particle count if possible
  3. hsCRP, ferritin, B12, vitamin D
  4. Thyroid panel (TSH + free T4)
  5. CBC with differential
  6. Liver panel (ALT, AST, GGT)
  7. DEXA scan or body composition

Total cost at Quest without insurance: ~$200. Worth every penny for the data.

Last edited: Mar 20, 2026 at 4:58 PM
38 8A1cHero_PHX, Dr.RenalNash, LipidDoc_ATL and 35 others
Reply Quote Save Share Report

Similar Threads

Survodutide MASH Phase 2b — histological improvement data9 replies
Semaglutide and MASH — liver fat reduction quantification13 replies
Non-invasive MASH biomarkers — FibroScan, ELF, FIB-4 on GLP-110 replies
ALT normalization rates on GLP-1 — pooled trial data20 replies
GLP-1 hepatoprotection — direct vs indirect mechanisms16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register