Following on from roxy_nash — and this may be the naive question:
How long did you give it before you decided it was working?
NicoleRaleigh said:lean mass + resistance training is the combo.
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the skeletal muscle fiber type distribution:
This "metabolic remodeling" of muscle may contribute to improved insulin sensitivity independent of total lean mass changes. The muscle you keep becomes metabolically better, even if there's less of it[1].
NicoleRaleigh said:lean mass + resistance training is the combo.
DEXA scan update relevant to lean mass:
Scanned at months 0, 6, and 12. Here are the body comp numbers:
| Baseline | Month 6 | Month 12 | |
|---|---|---|---|
| Total mass | 263 lbs | 223 lbs | 220 lbs |
| Fat mass | 123 lbs | 83 lbs | 55 lbs |
| Lean mass | 161 lbs | 154 lbs | 157 lbs |
| Body fat % | 40% | 34% | 24% |
Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.
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Browse GL BiochemNicoleRaleigh said:lean mass + resistance training is the combo.
This answered a question I did not know how to ask. I will report back once I have actually tried it.
Clinical perspective, offered as context rather than as advice.
Body composition tracking via bioimpedance on lean mass (InBody scan every 3 months):
| Metric | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Skeletal Muscle (lbs) | 70 | 70 | 69 | 72 |
| Body Fat (lbs) | 107 | 82 | 60 | 44 |
| Body Fat % | 40% | 33% | 25% | 22% |
| Visceral Fat (cm²) | 147 | 122 | 82 | 57 |
Note: skeletal muscle mass dipped initially then recovered with consistent resistance training + high protein. The visceral fat reduction is where the metabolic magic happens.