paige_pharma said:

PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

SaraMom3 said:

The mechanism is more central than most summaries suggest.

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

paige_pharma said:

PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.