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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionHas anyone dealt with muscle protein synthesis window? Page 3

Has anyone dealt with muscle protein synthesis window?

Dr.BariatricHTX Sun, Feb 8, 2026 at 10:38 AM 11 replies 821 viewsPage 3 of 3
Dr.ObesityLA
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Feb 10, 2026 at 8:23 PM#11
Dr.SportsMedIN said:
The RDA is the wrong reference and it is worth understanding why.

Agreed on the target, with the caveat that reference weight and current weight are different numbers. Using current weight at the start of a large loss produces a target that is both unachievable and unnecessary.

45 18zoe_NC, Dr.ObesityLA, NurseKim_ATL and 42 others
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DadBodDave
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Feb 11, 2026 at 4:27 AM#12
anders_CPH said:
Right, and protein targets should be set on a reference weight rather than current weight.

This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.

Last edited: Feb 11, 2026 at 7:27 AM
46 19JenMemphis, pat_auckland, Dr.GastroMayo and 43 others
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MounjBrad
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Feb 11, 2026 at 12:31 PM#13
Dr.SportsMedIN said:
The RDA is the wrong reference and it is worth understanding why.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

47 20nick_SD_fit, ben_calgary, patPC_UT and 44 others
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DataDave
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Feb 11, 2026 at 8:35 PM#14
Dr.BariatricHTX said:
I lifted three times a week throughout and still lost lean mass.

OMG yes. lean mass + resistance training is the combo. Can confirm.

Last edited: Feb 11, 2026 at 9:35 PM
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Admin
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Feb 12, 2026 at 4:38 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

49 22PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 46 others
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