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ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — why different people get different GI effects Page 3

Diarrhea vs constipation on GLP-1 — why different people get different GI effects

Dr.GutHealth Mon, May 25, 2026 at 11:45 PM 15 replies 580 viewsPage 3 of 3
GenomicsKate
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Jun 1, 2026 at 12:34 PM#11
Dr.ObesityMed said:
The escalation order that reflects the mechanism: water and salt first, then soluble fiber, then magnesium or an osmotic agent, then a stimulant only…

That reframing is the part I needed.

Last edited: Jun 1, 2026 at 5:34 PM
26 24DebRD_ATL, KristenIndy, MarkLI_maint and 23 others
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Dr.GastroMayo
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Jun 2, 2026 at 4:08 AM#12

From the other side of the consultation, briefly.

Heartburn management on constipation: Gaviscon before bed has been my savior. The delayed gastric emptying means stomach acid just sits there.

Don't ignore persistent heartburn — chronic acid exposure can damage your esophagus. If OTC remedies aren't cutting it after 2 weeks, see your doctor for something stronger. You shouldn't suffer through this.

Last edited: Jun 2, 2026 at 9:08 AM
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Dr.CardioMD
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Jun 2, 2026 at 7:42 PM#13
hyun_seoul said:
Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for…

Drug interaction alert relevant to constipation: if you take oral levothyroxine (Synthroid), GLP-1 agonists can reduce absorption due to delayed gastric emptying. My TSH drifted up after starting semaglutide.

Solution: take levothyroxine on an empty stomach, 60 minutes before any food, and have your TSH rechecked 6-8 weeks after starting or changing GLP-1 dose. My endo had to increase my Synthroid by 12.5mcg.

Last edited: Jun 3, 2026 at 1:42 AM
28 1tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 25 others
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NicoleRaleigh
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Jun 3, 2026 at 11:15 AM#14
Dr.GutHealth said:
Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally.

Sulfur burps on constipation — the most underrated side effect nobody warned me about. 🤢 The smell is absolutely vile and comes on without warning.

What finally helped: taking a digestive enzyme supplement. Also, eating smaller portions and chewing thoroughly reduces the gas production.

If sulfur burps persist beyond 2-3 weeks, talk to your provider — it could indicate gastroparesis that needs medical attention.

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mike_mod
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Jun 4, 2026 at 2:48 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

Last edited: Jun 4, 2026 at 4:48 AM
30 3PurityPaulOR, MaxMetOK, MounjBrad and 27 others
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