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ForumsSide Effects & ManagementMood changes on GLP-1 — depression, anxiety, or medication effect? Page 4

Mood changes on GLP-1 — depression, anxiety, or medication effect?

Dr.AddMedPHL Tue, May 19, 2026 at 7:17 PM 19 replies 547 viewsPage 4 of 4
Dr.EndoEP
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May 25, 2026 at 1:16 PM#16
rachel_ABQ said:
Before/after narrative for mental health — one year in: Before (270 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications,…

Same pattern here, and in the same order.

14 12NicoleRaleigh, james_edin, FranDenver and 11 others
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ingrid_STO
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May 25, 2026 at 8:49 PM#17

One thing that is still open after TrialTracker_MD’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

Last edited: May 25, 2026 at 11:49 PM
15 13COA_Karl, MikeFit_NJ, InsuranceTom and 12 others
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chris_chi24
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May 26, 2026 at 4:22 AM#18
raj_cambridge said:
When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 2. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

Last edited: May 26, 2026 at 7:22 AM
16 14MaxMetOK, MounjBrad, nick_newbie and 13 others
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rick_sfbay
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May 26, 2026 at 11:55 AM#19
raj_cambridge said:
When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

17 15FranDenver, Dr.BariatricHTX, LindaRN_retired and 14 others
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mike_mod
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May 26, 2026 at 7:28 PM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

Last edited: May 26, 2026 at 9:28 PM
39 12PurityPaulOR, MaxMetOK, MounjBrad and 36 others
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