hannah_MT said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

This is my experience too, for whatever a second data point is worth. Posting only so the count is not one.

hannah_MT said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Adding the part of the answer the thread has not reached. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Following on from hannah_MT — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

Dr.AddMedPHL said:

Say what you would expect to see if you were wrong, before you look.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

Ask again with the specifics and you will get a better answer than this one.