JennaRN said:

The liver data is among the strongest non-weight findings in the class.

I read this differently from JennaRN, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

Adding the numbers, since they settle part of this. With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most threads assume.

Dr.SleepRoch said:

The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

Adding the part of the answer the thread has not reached. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

One thing that is still open after Dr.BariatricHTX’s answer:

Whether normalised enzymes tell you anything about fibrosis, and what the right follow-up measurement is?

Closing the loop on my own question.

Coming back a few months on. It held. Nothing dramatic to report, which is the report.