ingrid_STO said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

There is a second half to this that has not been said yet. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.

I would rather be corrected than agreed with, if it comes to it.

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Correct me if the detail matters more than I have assumed.

One thing that is still open after ingrid_STO’s answer:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

Dr.AddMedPHL said:

Worth stating the units and the reference range whenever you post a number here.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

Dr.AddMedPHL said:

Worth stating the units and the reference range whenever you post a number here.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.