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ForumsSide Effects & ManagementJoint pain improvement vs new joint pain — a paradox on GLP-1 Page 3

Joint pain improvement vs new joint pain — a paradox on GLP-1

Dr.RheumBOS Fri, May 1, 2026 at 12:22 AM 28 replies 752 viewsPage 3 of 6
Dr.ReproEndo
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May 2, 2026 at 7:25 AM#11
PedsEndoPhilly said:
It helps to say which part of this you are uncertain about.

No disagreement with PedsEndoPhilly. One condition attached. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

21 19mona_PHX, andrew_nyc, Dr.EndoEP and 18 others
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kim_atl_prep
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May 2, 2026 at 4:55 PM#12
patPC_UT said:
Agreed on adaptation, with a caveat: adaptation applies to gastric emptying and not to everything.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

22 20BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 19 others
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pete_RVA
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May 3, 2026 at 2:25 AM#13
PedsEndoPhilly said:
It helps to say which part of this you are uncertain about.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

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anders_CPH
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May 3, 2026 at 11:55 AM#14

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

24 22BethLabQueen, ChrisMacros, KetoKyle and 21 others
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mike_mod
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May 3, 2026 at 9:25 PM#15

Moderator note: a couple of off-topic posts removed. No action needed from anybody.

25 23PurityPaulOR, MaxMetOK, MounjBrad and 22 others
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