SleepDoc_PDX said:

PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

VanRx_Mike said:

The pharmacokinetics explain nearly every practical question asked here.

That reframing is the part I needed. I will report back once I have actually tried it.

SleepDoc_PDX said:

PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.