Dr.PainCLE said:The mechanism that matters here is not stomach emptying, it is central.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
NurseAsh_DET said:Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.
Dr.PainCLE said:The mechanism that matters here is not stomach emptying, it is central.
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
Ask again with the specifics and you will get a better answer than this one.
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Browse GL BiochemSaraMom3 said:Two DEXA scans eleven months apart: down 24kg total, of which the scan says 6kg was lean.
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 275 | 240 | 235 | 205 |
| A1C (%) | 7.5 | 6.5 | 5.6 | 5.2 |
| hsCRP (mg/L) | 5.0 | 4.0 | 2.5 | 1.1 |
| Triglycerides | 225 | 175 | 135 | 115 |
Protocol: Tirzepatide 15mg/wk, resistance training 4x/week, protein 1.6g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.