Dr.BariatricHTX said:

The version of this that has an answer is narrower than the version being asked.

Adding the part of the answer the thread has not reached. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

One concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

One thing that is still open after Dr.BariatricHTX’s answer:

How to read a result like this without either dismissing it or over-reading it, since the summaries all read like press releases?

VendorMark said:

One practical note: write down what you did and when, before you need it.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

VendorMark said:

One practical note: write down what you did and when, before you need it.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.