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ForumsExercise & Body CompositionBody recomposition protocol: GLP-1 + progressive overload + high protein — May 2025

Body recomposition protocol: GLP-1 + progressive overload + high protein — May 2025

SkepticalSean Fri, Sep 26, 2025 at 9:18 PM 9 replies 1,138 viewsPage 1 of 2
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SkepticalSean
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Sep 26, 2025 at 9:18 PM#1

My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat more.

The bit I cannot resolve on my own is whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be.

Tell me what I have not thought of.

46 16DerekSJ_a1c, paige_pharma, emma_london and 43 others
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Dr.GastroMayo
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Sep 26, 2025 at 9:35 PM#2

Answering the narrow version, because the broad one does not have a single answer. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

Last edited: Sep 27, 2025 at 2:35 AM
45 15VendorMark, COA_Karl, MikeFit_NJ and 42 others
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TrialTracker_MD
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Sep 26, 2025 at 9:52 PM#3
Dr.GastroMayo said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

That is the short version; the long version is somebody else's post.

Last edited: Sep 27, 2025 at 2:52 AM
44 14maya_sedona, stefan_berlin, Dr.EM_Chicago and 41 others
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MASHdoc_SA
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Sep 26, 2025 at 10:09 PM#4
SkepticalSean said:
My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat…

Can confirm the pattern SkepticalSean describes. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

Last edited: Sep 27, 2025 at 1:09 AM
43 13LabKate, kate.chem, DataDave and 40 others
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PeptideChemSF
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Sep 26, 2025 at 11:38 PM#5

Clinical perspective, offered as context rather than as advice.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass262 lbs232 lbs219 lbs
Fat mass122 lbs82 lbs54 lbs
Lean mass160 lbs153 lbs156 lbs
Body fat %39%33%23%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.4g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

Last edited: Sep 27, 2025 at 3:38 AM
42 12BrianDallas92, labquiet_amy, emily_PDX and 39 others
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