TrialTracker_MD said:

The version of this that has an answer is narrower than the version being asked.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

JennaRN said:

Agreed, and ALT falling is not the same as fibrosis improving.

Thank you for spelling out the reasoning rather than just the conclusion.

TrialTracker_MD said:

The version of this that has an answer is narrower than the version being asked.

I read this differently from TrialTracker_MD, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.