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ForumsCOA & Analytical TestingHow to read a Certificate of Analysis — complete guide Page 20

How to read a Certificate of Analysis — complete guide

COA_Karl Mon, Feb 26, 2024 at 4:00 PM 245 replies 11,691 viewsPage 20 of 20
hank_denver
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Apr 7, 2024 at 3:57 AM#96

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

38 11ingrid_STO, pete_nash, hank_denver and 35 others
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NicoleRaleigh
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Apr 7, 2024 at 2:56 PM#97

A narrower follow-up, since the general answer is now clear:

Did your prescriber agree with that reading, and if not what was their objection?

39 12MikeFit_NJ, InsuranceTom, WendyG_ATL and 36 others
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COA_Karl
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Apr 8, 2024 at 1:55 AM#98

OP back with an update, since a thread like this is useless without one.

Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

40 13hyun_seoul, jim_asheville, matt_MKE and 37 others
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JenPlateau
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Apr 8, 2024 at 12:53 PM#99
hank_denver said:
One practical note: write down what you did and when, before you need it.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

41 14FitDadDave, RunnerRach, TrialNerd_Beth and 38 others
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SaraMom3
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Apr 8, 2024 at 11:51 PM#100

Coming back to something from earlier in the thread, because it keeps being talked past:

They are not contradictory, they measure different things, and this is the single most common misreading of a certificate. Purity is a relative area measurement: the main peak as a percentage of total peak area in the chromatogram. Content is an absolute mass measurement against a reference standard. A vial can be 99% pure and contain 6.1mg — pure material, overfilled — or 99% pure and contain 3mg, which is pure material and a short fill. Purity tells you what fraction of what is there is the right molecule; content tells you how much of it there is. You need both, and a certificate with only purity is telling you half the story.

50 5ZaraB_AL, JakeSmashed95, NauseaFreeNow and 47 others
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