Ok this is making me hopeful. I have terrible plantar fasciitis and ankle pain. I'm 3 weeks into sema and haven't noticed joint improvement yet. Is it too early?
Way too early! I didn't notice joint improvement until about month 3, and it was gradual — not a sudden "oh my knees don't hurt" moment. More like one day I realized I hadn't thought about my knees in a week. Give it time. The anti-inflammatory benefits build as both weight comes off and systemic inflammation decreases.
Adding some data on the inflammation markers for those interested:
| Marker | STEP 1 Baseline | STEP 1 Week 68 (sema) | Change |
|---|---|---|---|
| hsCRP (mg/L) | 3.8 | 1.6 | -58% |
| Fibrinogen (mg/dL) | 393 | 345 | -12% |
| TNF-α (pg/mL) | varies | — | ~30% reduction (subset data) |
A 58% reduction in CRP is massive. For context, statin therapy typically reduces CRP by about 15-30%. Semaglutide is a genuinely powerful anti-inflammatory agent.
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Browse GL BiochemStarting to think semaglutide is the most important drug developed in the last 20 years and I'm only half joking. Weight loss, blood sugar, cardiovascular protection, anti-inflammatory, joint protection, possible neuroprotection... what CAN'T it do? 😂