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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide mechanism of action: hypothalamic GLP-1R binding and satiety — what worked for you? Page 9

Semaglutide mechanism of action: hypothalamic GLP-1R binding and satiety — what worked for you?

VendorMark Fri, Jan 31, 2025 at 9:53 PM 54 replies 2,401 viewsPage 9 of 11
mia_MS2
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May 26, 2025 at 11:07 AM#41
carl_compliance said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Adding the part of the answer the thread has not reached. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: May 26, 2025 at 2:07 PM
36 9ricardo_MIA, BrianDallas92, labquiet_amy and 33 others
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PeptideChemSF
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May 31, 2025 at 7:52 AM#42

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

37 10dave_SLC, FDA_TrackerJim, ricardo_MIA and 34 others
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mike_mod
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Jun 5, 2025 at 4:34 AM#43

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.

38 11DoseLogDan, SleepFixSam, PurityPaulOR and 35 others
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HPLC_Greg
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Jun 10, 2025 at 1:13 AM#44
PeptideChemSF said:
Keep the original post as written when you update it, and add the correction underneath.

Pushing back on PeptideChemSF here. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Last edited: Jun 10, 2025 at 7:13 AM
39 12Dr.MetabolicMD, RetaRick_CA, JenPlateau and 36 others
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jason_sac26
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Jun 14, 2025 at 9:50 PM#45
PeptideChemSF said:
Keep the original post as written when you update it, and add the correction underneath.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

40 13Dr.PulmRoch, maya_sedona, stefan_berlin and 37 others
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