josh_phd_bmore said:I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.
That reframing is the part I needed.
From the other side of the consultation, briefly.
Lp(a) and cardiovascular risk: a nuance that matters. Unlike most lipid markers, Lp(a) is 90%+ genetically determined and doesn't really change with weight loss or GLP-1 therapy.
My Lp(a) has remained at 35 nmol/L across all time points. If yours is elevated (>50 nmol/L), you need additional risk mitigation strategies regardless of your GLP-1 response. Don't assume your medication is covering all cardiovascular risk factors.
Dr.GutHealth said:Lp(a) and cardiovascular risk: a nuance that matters.
Same experience, arrived at from the opposite direction. I had assumed I was the exception until I read this.
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View ResultsDr.GutHealth said:Lp(a) and cardiovascular risk: a nuance that matters.
There is a second half to this that has not been said yet. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
Dr.GutHealth said:Lp(a) and cardiovascular risk: a nuance that matters.
6 month update on cardiovascular risk: down 37 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.