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ForumsSemaglutide (Ozempic / Wegovy)Long-term semaglutide (3+ years) — need advice Page 3

Long-term semaglutide (3+ years) — need advice

EndoResFellow Thu, Dec 5, 2024 at 10:39 PM 11 replies 1,808 viewsPage 3 of 3
JessicaH_TX
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Dec 9, 2024 at 2:34 PM#11
LipidDoc_ATL said:
It helps to say which part of this you are uncertain about.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

Happy to go further on any of that.

Last edited: Dec 9, 2024 at 6:34 PM
26 24wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 23 others
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wanda_boise
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Dec 12, 2024 at 1:49 AM#12
wendy_avl said:
Steady state is the thing most people miss.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

27 0marco_milano, pam_columbus, nick_SD_fit and 24 others
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hannah_MT
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Dec 14, 2024 at 1:03 PM#13
LipidDoc_ATL said:
It helps to say which part of this you are uncertain about.

I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.

Last edited: Dec 14, 2024 at 4:03 PM
28 1MaxMetOK, MounjBrad, nick_newbie and 25 others
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stefan_berlin
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Dec 17, 2024 at 12:15 AM#14

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Dec 17, 2024 at 3:15 AM
29 2TirzTom, TrialTracker_MD, JennaRN and 26 others
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Admin
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Dec 19, 2024 at 11:26 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

Last edited: Dec 19, 2024 at 3:26 PM
30 3PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 27 others
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