KristenIndy said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Adding a me-too, because a thread of one person's experience is not much use. Nothing to add that would improve it.

KristenIndy said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Adding the part of the answer the thread has not reached. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

BethLabQueen said:

Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.