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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with glp-1 hepatoprotection? Page 3

Has anyone dealt with glp-1 hepatoprotection?

GenomicsKate Fri, Jul 11, 2025 at 12:32 PM 33 replies 1,678 viewsPage 3 of 7
DataDave
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Jul 12, 2025 at 10:41 PM#11
Dr.LipidDallas said:
Worth answering the question that was asked rather than the one behind it.

Agreeing with Dr.LipidDallas, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

3 1VendorMark, COA_Karl, MikeFit_NJ
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roxy_nash
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Jul 13, 2025 at 9:54 AM#12
BrianDallas92 said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

Last edited: Jul 13, 2025 at 3:54 PM
4 2roxy_nash, tony_orlando, Dr.NephBHM_UK and 1 other
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BenResearch_OR
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Jul 13, 2025 at 9:07 PM#13
Dr.LipidDallas said:
Worth answering the question that was asked rather than the one behind it.

Pushing back on Dr.LipidDallas here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Last edited: Jul 13, 2025 at 10:07 PM
5 3Dr.NateNeph, PharmD_Rodriguez, julia.endo and 2 others
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Dr.AddMedPHL
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Jul 14, 2025 at 8:20 AM#14

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Jul 14, 2025 at 10:20 AM
6 4TomFromTexas, mike.trainer_LA, sarah_nash92 and 3 others
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Admin
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Jul 14, 2025 at 7:33 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

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