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ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — looking for input Page 7

MASH resolution without worsening fibrosis — looking for input

PeptideSynthNJ Wed, Jul 2, 2025 at 8:50 AM 40 replies 1,673 viewsPage 7 of 8
sean_dublin
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Dublin, IE
Sep 28, 2025 at 1:51 PM#31

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Last edited: Sep 28, 2025 at 2:51 PM
49 22hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 46 others
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Dr.ReproEndo
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Scottsdale, AZ
Oct 5, 2025 at 4:19 AM#32
sean_dublin said:
The mechanism and the magnitude are separate questions.

Can confirm. Same sequence, different timescale. Nothing to add that would improve it.

Last edited: Oct 5, 2025 at 5:19 AM
50 23andrew_nyc, Dr.EndoEP, GraceAZ_72 and 47 others
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roxy_nash
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Nashville, TN
Oct 11, 2025 at 6:43 PM#33
sean_dublin said:
The mechanism and the magnitude are separate questions.

Coming at sean_dublin’s question from a different direction. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

1 24tony_orlando
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wendy_avl
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Asheville, NC
Oct 18, 2025 at 9:04 AM#34

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

2 0PharmHunterJen, TomTeleRx
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carl_compliance
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Raleigh, NC
Oct 24, 2025 at 11:21 PM#35

One thing that is still open after sean_dublin’s answer:

How would you tell the difference between that and the alternative explanation?

3 1dave_SLC, FDA_TrackerJim, ricardo_MIA
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