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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingPaid for independent testing and results did not match vendor COA Page 2

Paid for independent testing and results did not match vendor COA

PurityPaulOR Sat, May 9, 2026 at 3:54 AM 36 replies 1,050 viewsPage 2 of 8
LarryQC_SD
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May 9, 2026 at 11:20 PM#6
Dr.RenalNash said:
The useful checklist is about verifiability rather than presentation.

I disagree that testing history is decisive. It tells you what a supplier did when they were being watched. Continuity of behaviour under stress — a late shipment, a failed test, a complaint — is more predictive than any run of good results.

Last edited: May 10, 2026 at 12:20 AM
8 3NurseKim_ATL, paul_denver, TinaHashiRN and 5 others
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LabKate
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May 10, 2026 at 7:03 AM#7

The figures, for anyone assembling their own picture. The four things to check on any report, in order: does it name your batch, who commissioned it, what method was used, and does it report content as well as purity. A report failing any of those is weak evidence regardless of the percentage on it.

7 2laura_annarbor, JenMemphis, pat_auckland and 4 others
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Dr.ObesityMed
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May 10, 2026 at 2:46 PM#8
LarryQC_SD said:
I disagree that testing history is decisive.

Adding the part of the answer the thread has not reached. They are not contradictory, they measure different things, and this is the single most common misreading of a certificate. Purity is a relative area measurement: the main peak as a percentage of total peak area in the chromatogram. Content is an absolute mass measurement against a reference standard. A vial can be 99% pure and contain 6.1mg — pure material, overfilled — or 99% pure and contain 3mg, which is pure material and a short fill. Purity tells you what fraction of what is there is the right molecule; content tells you how much of it there is. You need both, and a certificate with only purity is telling you half the story.

6 1SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 3 others
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Sigma-Aldrich — Research-Grade Standards

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FranDenver
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May 10, 2026 at 10:29 PM#9

Following on from FitDadDave — and this may be the naive question:

What a vetting checklist should actually contain, as opposed to a list of things that are easy to fake?

Last edited: May 11, 2026 at 4:29 AM
5 0MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 2 others
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PurityPaulOR
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May 12, 2026 at 11:34 AM#10

Reporting back.

Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality changed. I was reading the product and not the behaviour.

21 19mike_mod, SarahChen_PharmD, sarah.morrison and 18 others
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