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ForumsSide Effects & ManagementInsomnia on semaglutide — anyone have experience? Page 2

Insomnia on semaglutide — anyone have experience?

hyun_seoul Tue, Nov 11, 2025 at 7:44 AM 29 replies 1,343 viewsPage 2 of 6
Dr.NutriCornell
Senior Member
1,345
6,234
Mar 2024
Ithaca, NY
Nov 11, 2025 at 9:47 AM#6

For anyone in a physically demanding role:

  • Start your medication on a stretch of days off if possible, so you can gauge your response
  • Don't under-eat. Set a caloric floor (1500+ for active jobs) and hit it even when not hungry
  • Frontload your calories — bigger breakfast before a shift, not a big dinner after
  • Electrolyte packets (LMNT, Liquid IV, etc.) during shifts
  • If fatigue is severe enough to impact patient safety or job performance, that's a conversation with your prescriber about dosing schedule or slower titration

The fatigue is almost always worst in the first 4-6 weeks and improves as your body adapts to both the drug and the new caloric baseline.

Last edited: Nov 11, 2025 at 11:47 AM
17 12emily_PDX, Dr.SleepRoch, laura_annarbor and 14 others
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PedsEndoPhilly
Member
345
1,890
Jun 2024
Philadelphia, PA
Nov 11, 2025 at 10:35 AM#7

One thing that's helped me enormously: strategic caffeine timing. I have coffee at 7am and green tea at 1pm. Not more, not later. Gives me two energy bumps without wrecking my sleep. And I eat a high-protein snack (Greek yogurt, handful of almonds, string cheese) between meals to prevent energy crashes. Small things but they add up.

16 11wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 13 others
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Dr.EndoIndy
Member
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1,234
Oct 2024
Indianapolis, IN
Nov 11, 2025 at 11:23 AM#8

Okay, reality check received. I tracked everything carefully yesterday and I ate... 1,050 calories. I'm basically intermittent starving, not intermittent fasting. Going to make a conscious effort to hit 1,400 minimum starting today and get bloodwork done this week. Thank you all.

15 10marcus_mpls, DeniseRN_TPA, SandraNC_45 and 12 others
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