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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementTMI but the constipation is REAL — what worked for you? Page 2

TMI but the constipation is REAL — what worked for you?

bbq_ray_KC Fri, Sep 26, 2025 at 5:31 PM 8 replies 1,186 viewsPage 2 of 2
VendorMark
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Sep 26, 2025 at 8:45 PM#6
kate.chem said:
Fiber trials in this population are thin, and most of what gets quoted is extrapolated from idiopathic constipation in people eating normally.

Worth saying plainly that not all of this is benign. Severe constipation on delayed gastric emptying has produced obstruction and ileus cases, rarely but genuinely. Pain with vomiting and no bowel movement is not a fiber conversation.

That is the short version; the long version is somebody else's post.

Last edited: Sep 26, 2025 at 10:45 PM
3 23DebRD_ATL, KristenIndy, MarkLI_maint
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quinn_sf
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Sep 26, 2025 at 10:01 PM#7
bbq_ray_KC said:
I added fiber, made it noticeably worse, and only later worked out that I had added the bulk without adding the water.

Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for hours after a small meal.

Tips: eat your protein FIRST (most important macro), then vegetables, then carbs last. Chew thoroughly — 20-30 chews per bite isn't excessive. Avoid carbonated beverages with meals. If symptoms are severe, your doctor may recommend a gastric emptying study.

Last edited: Sep 27, 2025 at 4:01 AM
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Dr.KarenChen
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Sep 26, 2025 at 11:17 PM#8
VendorMark said:
Worth saying plainly that not all of this is benign.

Acid reflux and constipation: I developed GERD symptoms around week 7 that I'd never had before. The delayed gastric emptying means food and acid sit in your stomach longer.

Management that works for me: elevate head of bed 6 inches, don't eat within 3 hours of lying down, avoid trigger foods (tomato, citrus, spicy, chocolate), and famotidine 20mg at bedtime. Much better now.

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GraceAZ_72
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Sep 27, 2025 at 12:33 AM#9

A narrower follow-up, since the general answer is now clear:

Whether fiber actually helps GLP-1 constipation or whether the evidence is borrowed from a different population?

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bbq_ray_KC
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Sep 27, 2025 at 6:38 AM#10

OP back with an update, since a thread like this is useless without one.

Resolved: water and magnesium first, soluble fibre second, bran gone entirely. Two months of doing it in the wrong order and a week to undo.

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