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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSemaglutide (Ozempic / Wegovy)Can I drink on sema or will I die — need advice Page 3

Can I drink on sema or will I die — need advice

Dr.LeslieOBGYN Wed, Jan 24, 2024 at 4:47 AM 14 replies 2,106 viewsPage 3 of 3
JessicaH_TX
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Jan 25, 2024 at 12:17 PM#11
JenPlateau said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

48 21wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 45 others
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lucas_SP_BR
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Jan 25, 2024 at 11:55 PM#12
Dr.PathRoch said:
Steady state is the thing most people miss.

Bookmarking. The distinction being drawn above is the one nobody else makes.

49 22Dr.ObesityLA, NurseKim_ATL, paul_denver and 46 others
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PeptideChemSF
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Jan 26, 2024 at 11:33 AM#13
JenPlateau said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

Last edited: Jan 26, 2024 at 3:33 PM
50 23FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 47 others
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raj_cambridge
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Jan 26, 2024 at 11:11 PM#14

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Last edited: Jan 27, 2024 at 12:11 AM
1 24PharmHunterJen
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Jan 27, 2024 at 10:48 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

2 0PeptideSynthNJ, Dr.KarenChen
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