Taking the question as asked, rather than the general version of it. They are not contradictory, they measure different things, and this is the single most common misreading of a certificate. Purity is a relative area measurement: the main peak as a percentage of total peak area in the chromatogram. Content is an absolute mass measurement against a reference standard. A vial can be 99% pure and contain 6.1mg — pure material, overfilled — or 99% pure and contain 3mg, which is pure material and a short fill. Purity tells you what fraction of what is there is the right molecule; content tells you how much of it there is. You need both, and a certificate with only purity is telling you half the story.
Two reports on the same product from two laboratories, four percentage points apart, and no method stated on either.
The narrow version of the question is whether a purity figure and a content figure can disagree without one of them being wrong.
Tell me what I have not thought of.
NurseKim_ATL said:They are not contradictory, they measure different things, and this is the single most common misreading of a certificate.
No disagreement with NurseKim_ATL. One condition attached. One addition: an unstated method makes a report close to uninterpretable. "99% pure" without the technique, the standard and the conditions is a claim, not a measurement.
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Shop Reference StandardsDr.RaviCardio said:Two reports on the same product from two laboratories, four percentage points apart, and no method stated on either.
Can confirm the pattern Dr.RaviCardio describes. The provenance questions are more useful than the numbers. Does the report name the batch on your vial. Is the date consistent with when that batch existed. Is it addressed to the vendor or to the person who paid for the test. Was the sample taken from general stock or supplied by the vendor. A perfect certificate for a different batch is worth nothing, and vendor-supplied samples are the most common way a genuine report ends up misleading.
Clinical perspective, offered as context rather than as advice.
Third-party testing services for certificates of analysis besides Janoshik:
- Janoshik: Gold standard for peptide community, ~$139, 10-14 day turnaround
- Valitech: US-based, ISO 17025 accredited, ~$219
- Eurofins: Full pharmaceutical testing suite, more expensive but comprehensive
- ChemTox: Basic identity and purity testing, ~$109
Janoshik is the community standard but any ISO-accredited analytical lab can verify peptide identity and purity. The key is independence — don't rely solely on the vendor's own testing.