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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsHas anyone dealt with insulin discontinued?

Has anyone dealt with insulin discontinued?

MikeFit_NJ Mon, Nov 10, 2025 at 11:01 PM 18 replies 1,254 viewsPage 1 of 4
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MikeFit_NJ
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Nov 10, 2025 at 11:01 PM#1

Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.

Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

Where I think it is weakest: the comparator does most of the work in how this gets reported, and it is not the comparator most people think they are citing.

The question I want answered is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything. Tell me what I have not thought of.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
19 14LeilaHI, marcus_mpls, DeniseRN_TPA and 16 others
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Dr.GastroMayo
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Nov 10, 2025 at 11:44 PM#2
MikeFit_NJ said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

Plateau breaking story with a stall: I stalled at 195 lbs for 8 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: adding HIIT cardio 2x/week. Lost 10 lbs in the next 3 weeks. Plateaus are temporary — they always break if you stay consistent.

Last edited: Nov 11, 2025 at 4:44 AM
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LibrarianMeg
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Nov 11, 2025 at 12:27 AM#3
MikeFit_NJ said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

Pushing back on MikeFit_NJ here. The "it is your intake" reflex here gets tiring. Some people genuinely stop responding at a dose that worked, and telling them to track harder when they have already tracked is how people stop posting.

17 12julia.endo, JessicaM_2024, TomFromTexas and 14 others
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TrialNerd_Beth
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Nov 11, 2025 at 1:10 AM#4

Short answer first, then the reasoning. Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

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roxy_nash
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Nov 11, 2025 at 5:13 AM#5
Dr.GastroMayo said:
Plateau breaking story with a stall: I stalled at 195 lbs for 8 weeks.

Can confirm. Same sequence, different timescale.

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