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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsCRP from 12.4 to 0.8 — 12 month update

CRP from 12.4 to 0.8 — 12 month update

PharmHunterJen Sun, Oct 19, 2025 at 5:21 PM 38 replies 2,042 viewsPage 1 of 8
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PharmHunterJen
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Oct 19, 2025 at 5:21 PM#1

Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several times.

What I am after is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything.

Numbers rather than impressions, if you have them.

15 10Dr.LipidDallas, alex_tucson, kevin_tulsa and 12 others
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MikeFit_NJ
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Oct 19, 2025 at 5:36 PM#2
PharmHunterJen said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Plateau breaking story with a stall: I stalled at 200 lbs for 6 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: increasing protein to 150g/day. Lost 9 lbs in the next 2 weeks. Plateaus are temporary — they always break if you stay consistent.

Last edited: Oct 19, 2025 at 8:36 PM
14 9marcus_mpls, DeniseRN_TPA, SandraNC_45 and 11 others
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sarah_TO
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Oct 19, 2025 at 5:51 PM#3
MikeFit_NJ said:
Plateau breaking story with a stall: I stalled at 200 lbs for 6 weeks.

MikeFit_NJ has the substance of this right. The condition it depends on is worth stating. Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

Last edited: Oct 19, 2025 at 9:51 PM
13 8GraceAZ_72, carl_compliance, DanielChem_CHI and 10 others
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paul_denver
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Denver, CO
Oct 19, 2025 at 6:06 PM#4
PharmHunterJen said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

This is my experience too, for whatever a second data point is worth. Posting only so the count is not one.

12 7sarah_TO, wendy_avl, jason_paloalto and 9 others
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Dr.RaviCardio
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Oct 19, 2025 at 7:27 PM#5

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

11 6jason_sac26, chris_chi24, tampaLisa73 and 8 others
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