TinaHashiRN said:The GIP arm is doing real work rather than padding the label.
True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of people never reach the dose the headline number came from.
Dr.NateNeph said:The meal advice is right and incomplete without the hydration point.
That reframing is the part I needed. Adding it to my notes with a link back to this thread.
TinaHashiRN said:The GIP arm is doing real work rather than padding the label.
Pushing back on TinaHashiRN here. The "tirzepatide is simply better" summary irritates me. It is better on mean weight loss, and the cardiovascular outcome evidence is far thinner than semaglutide's. If the reason for treating is cardiovascular risk rather than weight, the evidence base points the other way.
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View ResultsAdding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.