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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsHas anyone dealt with one hundred pounds down lets gooo?

Has anyone dealt with one hundred pounds down lets gooo?

DanielChem_CHI Tue, Apr 15, 2025 at 5:09 PM 25 replies 1,966 viewsPage 1 of 5
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DanielChem_CHI
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Apr 15, 2025 at 5:09 PM#1

This gets cited here weekly, usually second-hand, so it is worth setting out what it does and does not establish.

Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

Where I think it is weakest: the subgroup findings are the part I trust least — with enough subgroups something is always significant, and these were not all pre-registered.

What I am after is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything. I have searched first, so if this is covered somewhere point me at it and I will read it.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
15 10fiona_VT, denise_HTX, raj_cambridge and 12 others
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KevinCompounds
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Apr 15, 2025 at 5:38 PM#2
DanielChem_CHI said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

Plateau breaking story with a stall: I stalled at 206 lbs for 7 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: a brief dose increase followed by return to maintenance. Lost 8 lbs in the next 3 weeks. Plateaus are temporary — they always break if you stay consistent.

Last edited: Apr 15, 2025 at 7:38 PM
14 9Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 11 others
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labquiet_amy
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Apr 15, 2025 at 6:07 PM#3
DanielChem_CHI said:
Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The "it is your intake" reflex here gets tiring. Some people genuinely stop responding at a dose that worked, and telling them to track harder when they have already tracked is how people stop posting.

13 8LibrarianMeg, bri_stats, pete_manc_UK and 10 others
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pete_nash
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Apr 15, 2025 at 6:36 PM#4

This one has a reasonably settled answer, so here it is. Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

12 7SarahChen_PharmD, sarah.morrison, NeuroNate and 9 others
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steve_okc
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Apr 15, 2025 at 9:15 PM#5
KevinCompounds said:
Plateau breaking story with a stall: I stalled at 206 lbs for 7 weeks.

Mine went the same way, slower.

11 6KetoKyle, CanadaChris, ZaraB_AL and 8 others
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