🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingHas anyone dealt with moisture content analysis for lyophilized peptides? Page 7

Has anyone dealt with moisture content analysis for lyophilized peptides?

zoe_NC Mon, Oct 20, 2025 at 10:26 AM 31 replies 1,698 viewsPage 7 of 7
matt_MKE
Member
312
1,345
Sep 2024
Milwaukee, WI
Mar 4, 2026 at 1:53 PM#31
zoe_NC said:
Update: the thing I was blaming turned out not to be the cause.

Pushing back on zoe_NC here. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

8 8andrew_nyc, Dr.EndoEP, GraceAZ_72 and 5 others
Reply Quote Save Share Report
mia_MS2
New Member
8
23
Jun 2026
Ann Arbor, MI
Mar 15, 2026 at 12:44 PM#32
zoe_NC said:
Update: the thing I was blaming turned out not to be the cause.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

7 7FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 4 others
Reply Quote Save Share Report
pete_nash
Member
312
1,345
Aug 2024
Nashville, TN
Mar 26, 2026 at 11:41 AM#33
zoe_NC said:
Update: the thing I was blaming turned out not to be the cause.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

6 6mike_mod, SarahChen_PharmD, sarah.morrison and 3 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
Dr.ReproEndo
Senior Member
1,890
8,901
Jan 2024
Scottsdale, AZ
Apr 6, 2026 at 10:44 AM#34

Adding the clinical framing, because it changes how the question reads. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

5 5GraceAZ_72, carl_compliance, DanielChem_CHI and 2 others
Reply Quote Save Share Report
MarkLI_maint
Member
534
2,345
Jun 2024
Long Island, NY
Apr 17, 2026 at 9:54 AM#35
Dr.ReproEndo said:
It is worth asking what the claim would look like if it were false.

Can confirm. Same sequence, different timescale. I had assumed I was the exception until I read this.

4 4bri_stats, pete_manc_UK, anna.melb_AU and 1 other
Reply Quote Save Share Report
1567

Similar Threads

HPLC vs UPLC for peptide purity — method comparison study18 replies
Mass spectrometry for peptide identity verification — ESI-MS guide7 replies
Endotoxin testing methods — LAL vs recombinant Factor C17 replies
Red flags on COAs — how to spot a fake certificate5 replies
USP reference standards for peptide verification — sourcing guide3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register