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ForumsSide Effects & ManagementHair falling out at month 4 - freaking out — looking for input

Hair falling out at month 4 - freaking out — looking for input

marcus_mpls Tue, Sep 24, 2024 at 2:43 AM 19 replies 2,179 viewsPage 1 of 4
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marcus_mpls
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Nov 2024
Minneapolis, MN
Sep 24, 2024 at 2:43 AM#1

The nausea I get is not really nausea, it is an aversion. Food I want in the abstract becomes repellent in front of me, which no side-effect list describes.

Trial-level incidence runs roughly 20 to 25% for nausea at the higher dose tiers and 12 to 17% for diarrhoea, with most events mild to moderate and concentrated in the weeks after each escalation.

What I am after is whether holding at a lower dose for longer actually reduces total side-effect burden or just spreads it out.

Numbers rather than impressions, if you have them.

3 23bbq_ray_KC, oliver_london, tane_welly
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PeptideChemSF
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Jan 2024
San Francisco, CA
Sep 24, 2024 at 3:21 AM#2

Taking the question as asked, rather than the general version of it. The line between titrate-through and stop is not severity, it is trajectory and what else is present. Nausea that peaks and improves within a week is the expected pattern. Nausea that is escalating, or that comes with severe upper-abdominal pain radiating to the back, or that prevents fluids for more than a day, is a different conversation and belongs with a clinician the same day.

Last edited: Sep 24, 2024 at 7:21 AM
2 22dave_SLC, FDA_TrackerJim
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DataDave
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Sep 24, 2024 at 3:59 AM#3
PeptideChemSF said:
The line between titrate-through and stop is not severity, it is trajectory and what else is present.

That is correct as far as it goes, and here is where it stops going. The meal advice is right and incomplete without the hydration point. People stop drinking because drinking makes them feel full, then attribute dehydration symptoms to the drug.

Last edited: Sep 24, 2024 at 4:59 AM
1 21LondonLisa
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oliver_london
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Aug 2024
London, UK
Sep 24, 2024 at 4:37 AM#4
marcus_mpls said:
The nausea I get is not really nausea, it is an aversion.

Can confirm the pattern marcus_mpls describes. The practical protocol is dull and it works: smaller meals, stop eating at the first sign of fullness rather than at the end of the plate, drop the fat fraction of meals in the two days after dosing, and do not lie down straight after eating. Most of what people call unmanageable nausea is a meal-size and meal-composition problem interacting with a stomach that is emptying slowly.

50 20jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 47 others
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lisa_labSD
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Oct 2024
San Diego, CA
Sep 24, 2024 at 8:11 AM#5

From the other side of the consultation, briefly. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

49 19cory_ATX, lori_vegas, Dr.PulmRoch and 46 others
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