Dr.Martinez said:

Worth answering the question that was asked rather than the one behind it.

All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.

That is the short version; the long version is somebody else's post.

AmyNC_wife said:

The mechanism that matters here is not stomach emptying, it is central.

This answered a question I did not know how to ask. I will report back once I have actually tried it.

Dr.Martinez said:

Worth answering the question that was asked rather than the one behind it.

I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.