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ForumsCOA & Analytical TestingMass spectrometry for peptide identity verification — March 2026 Page 8

Mass spectrometry for peptide identity verification — March 2026

JakeBK_lifts Thu, Oct 31, 2024 at 6:08 AM 37 replies 2,134 viewsPage 8 of 8
VendorMark
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Dec 8, 2024 at 3:54 PM#36

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: Dec 8, 2024 at 5:54 PM
44 17DebRD_ATL, KristenIndy, MarkLI_maint and 41 others
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TinaHashiRN
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Dec 10, 2024 at 10:31 AM#37

One thing that is still open after Dr.Martinez’s answer:

How long did you give it before you decided it was working?

45 18mike_mod, SarahChen_PharmD, sarah.morrison and 42 others
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RunnerRach
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Dec 12, 2024 at 5:07 AM#38
VendorMark said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Pushing back on VendorMark here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Last edited: Dec 12, 2024 at 8:07 AM
46 19Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 43 others
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tammy_FL
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Dec 13, 2024 at 11:42 PM#39
VendorMark said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Last edited: Dec 14, 2024 at 5:42 AM
47 20Dr.PainCLE, mike_mealprep, NicoleRaleigh and 44 others
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PeptideSynthNJ
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Dec 15, 2024 at 6:16 PM#40
VendorMark said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

Last edited: Dec 15, 2024 at 10:16 PM
19 17Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 16 others
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