One thing that is still open after TrialNerd_Beth’s answer:

What did you change at the same time, and can you separate the two now?

MASHdoc_SA said:

My vendor review relevant to certificates of analysis: ordered 6 times from my current compounder.

COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis:

• No HPLC data: If there's no chromatography graph, it's not a real COA
• Exact 100% purity: Suspicious — real testing always shows slight variation
• No batch number: Can't trace back to specific production
• No endotoxin testing: For injectables, this is essential
• Template looks like it was made in Word: Professional labs have standardized formats

I have seen fake COAs that are literally photoshopped. Always verify independently if possible.

MASHdoc_SA said:

My vendor review relevant to certificates of analysis: ordered 6 times from my current compounder.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Happy to go further on any of that.

MASHdoc_SA said:

My vendor review relevant to certificates of analysis: ordered 6 times from my current compounder.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

From the other side of the consultation, briefly. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.