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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingLC-MS/MS vs HPLC for peptide analysis — November 2025 Page 6

LC-MS/MS vs HPLC for peptide analysis — November 2025

Dr.SportsMedIN Mon, Jul 22, 2024 at 3:37 PM 51 replies 2,260 viewsPage 6 of 11
GenomicsKate
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Sep 12, 2024 at 1:53 PM#26
hank_denver said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

47 20DebRD_ATL, KristenIndy, MarkLI_maint and 44 others
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PeptideChemSF
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Sep 19, 2024 at 9:32 AM#27

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Correct me if the detail matters more than I have assumed.

48 21dave_SLC, FDA_TrackerJim, ricardo_MIA and 45 others
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maya_sedona
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Sep 26, 2024 at 5:08 AM#28
PeptideChemSF said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Same pattern here, and in the same order. Posting only so the count is not one.

49 22BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 46 others
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Dr.LipidDallas
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Oct 3, 2024 at 12:40 AM#29
PeptideChemSF said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Adding the part of the answer the thread has not reached. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

Correct me if the detail matters more than I have assumed.

Last edited: Oct 3, 2024 at 2:40 AM
50 23lori_vegas, Dr.PulmRoch, maya_sedona and 47 others
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Dr.SportsMedIN
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Oct 9, 2024 at 8:08 PM#30

Closing the loop on my own question.

Resolved, and the thing that resolved it was the least interesting suggestion in the thread. Writing that down for the next person who wants the interesting answer.

22 20rachel_ABQ, traveltech_sara, AttorneyGrant and 19 others
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