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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingParticulate matter testing — 6 month update Page 3

Particulate matter testing — 6 month update

SarahChen_PharmD Fri, Apr 19, 2024 at 2:09 AM 14 replies 1,992 viewsPage 3 of 3
PharmacoVig_BOS
Senior Member
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Apr 21, 2024 at 8:17 AM#11
claudia_zurich said:
I tested my certificates of analysis batch through Janoshik — 98.1% purity.

COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis:

  • No HPLC data: If there's no chromatography graph, it's not a real COA
  • Exact 100% purity: Suspicious — real testing always shows slight variation
  • No batch number: Can't trace back to specific production
  • No endotoxin testing: For injectables, this is essential
  • Template looks like it was made in Word: Professional labs have standardized formats

I have seen fake COAs that are literally photoshopped. Always verify independently if possible.

11 9amsterdam_pete, LondonLisa, mike_nyc and 8 others
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stefan_berlin
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Berlin, DE
Apr 21, 2024 at 12:41 PM#12
ricardo_MIA said:
One addition: an unstated method makes a report close to uninterpretable.

Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.

Last edited: Apr 21, 2024 at 3:41 PM
12 10JessicaH_TX, KevinCompounds, TirzTom and 9 others
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Dr.EndoIndy
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Indianapolis, IN
Apr 21, 2024 at 5:05 PM#13
claudia_zurich said:
I tested my certificates of analysis batch through Janoshik — 98.1% purity.

Third-party testing services for certificates of analysis besides Janoshik:

  • Janoshik: Gold standard for peptide community, ~$136, 10-14 day turnaround
  • Valitech: US-based, ISO 17025 accredited, ~$216
  • Eurofins: Full pharmaceutical testing suite, more expensive but comprehensive
  • ChemTox: Basic identity and purity testing, ~$106

Janoshik is the community standard but any ISO-accredited analytical lab can verify peptide identity and purity. The key is independence — don't rely solely on the vendor's own testing.

Last edited: Apr 21, 2024 at 8:05 PM
13 11marcus_mpls, DeniseRN_TPA, SandraNC_45 and 10 others
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Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
lisa_labSD
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Oct 2024
San Diego, CA
Apr 21, 2024 at 9:29 PM#14
SarahChen_PharmD said:
Two reports on the same product from two laboratories, four percentage points apart, and no method stated on either.

My vendor review relevant to certificates of analysis: ordered 3 times from my current compounder. Consistency has been excellent.

Shipping: Next-day with cold pack
Packaging: Professional, discreet, proper labeling with lot/batch numbers
Purity: 97.0% average across orders (Janoshik verified)
Customer service: Responsive within 2 hours
Price: $128/month for semaglutide 2.4mg equivalent

Last edited: Apr 22, 2024 at 12:29 AM
14 12lori_vegas, Dr.PulmRoch, maya_sedona and 11 others
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Admin
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Apr 22, 2024 at 1:52 AM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.

15 13PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 12 others
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