DanielChem_CHI said:

Practical: whatever you change, write down the date and the reason.

I read this differently from DanielChem_CHI, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

DanielChem_CHI said:

Practical: whatever you change, write down the date and the reason.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

PharmHunterJen said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Same pattern here, and in the same order.