One thing that is still open after Dr.RaviCardio’s answer:
Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?
sarah_nash92 said:The mechanism is more central than most summaries suggest.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.
Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
sarah_nash92 said:The mechanism is more central than most summaries suggest.
Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.
I would rather be corrected than agreed with, if it comes to it.
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Browse GL Biochemsarah_nash92 said:The mechanism is more central than most summaries suggest.
This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.
Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.