rachel_ABQ said:

The mechanism and the magnitude are separate questions.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

WendyG_ATL said:

Agreed, with a caveat about community reputation: it is a lagging indicator.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

rachel_ABQ said:

The mechanism and the magnitude are separate questions.

Pushing back on rachel_ABQ here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: the sourcing question belongs in the vendor section and has been split out.