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ForumsPharmacology & MechanismsSemaglutide albumin binding and the C-18 fatty acid linker — anyone have experience? Page 5

Semaglutide albumin binding and the C-18 fatty acid linker — anyone have experience?

cory_ATX Fri, May 1, 2026 at 1:07 AM 27 replies 1,145 viewsPage 5 of 6
SarahChen_PharmD
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May 5, 2026 at 9:11 AM#21

From the other side of the consultation, briefly. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

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DeniseRN_TPA
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May 6, 2026 at 2:56 AM#22
SarahChen_PharmD said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Mine went the same way, slower. Nothing to add that would improve it.

Last edited: May 6, 2026 at 5:56 AM
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PurityPaulOR
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May 6, 2026 at 8:40 PM#23
SarahChen_PharmD said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Adding the part of the answer the thread has not reached. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

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Dr.PulmRoch
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May 7, 2026 at 2:24 PM#24

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: May 7, 2026 at 3:24 PM
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zoe_NC
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May 8, 2026 at 8:08 AM#25

Following on from SarahChen_PharmD — and this may be the naive question:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

Last edited: May 8, 2026 at 9:08 AM
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