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ForumsDosing & ProtocolsSemaglutide PK modeling — anyone have experience? Page 7

Semaglutide PK modeling — anyone have experience?

anna.melb_AU Fri, Jan 31, 2025 at 11:07 AM 31 replies 2,196 viewsPage 7 of 7
sarah_TO
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Apr 11, 2025 at 5:55 AM#31
BethLabQueen said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

36 9andrew_nyc, Dr.EndoEP, GraceAZ_72 and 33 others
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NurseKim_ATL
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Atlanta, GA
Apr 16, 2025 at 1:04 PM#32

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

37 10raj_cambridge, ingrid_STO, pete_nash and 34 others
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B12Beth
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Apr 21, 2025 at 8:10 PM#33
NurseKim_ATL said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Mine went the same way, slower. Nothing to add that would improve it.

Last edited: Apr 21, 2025 at 11:10 PM
38 11DanielChem_CHI, marco_milano, pam_columbus and 35 others
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Dr.MetabolicMD
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Apr 27, 2025 at 3:13 AM#34
NurseKim_ATL said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at NurseKim_ATL’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

39 12Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 36 others
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BiostatsBrad
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Durham, NC
May 2, 2025 at 10:13 AM#35

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Last edited: May 2, 2025 at 11:13 AM
40 13NicoleRaleigh, james_edin, FranDenver and 37 others
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