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ForumsMetabolic Health & DiabetesGLP-1 and gluconeogenesis — my results so far

GLP-1 and gluconeogenesis — my results so far

carlos_SATX Tue, Mar 10, 2026 at 7:15 AM 11 replies 875 viewsPage 1 of 3
carlos_SATX
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1,123
Oct 2024
San Antonio, TX
Mar 10, 2026 at 7:15 AM#1

Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

The question I want answered is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

Not looking for reassurance. Looking for the part I have got wrong.

4 24james_edin, FranDenver, Dr.BariatricHTX and 1 other
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BethLabQueen
Senior Member
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5,678
May 2024
Virginia
Online
Mar 10, 2026 at 7:34 AM#2
carlos_SATX said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 40% to 22%. Target is <36%, with <30% being ideal.

Why this matters more than average glucose: large glucose swings cause oxidative stress, endothelial damage, and promote advanced glycation end-products (AGEs). A flat glucose line at 95 mg/dL is metabolically healthier than oscillating between 60 and 160, even if the average is the same.

3 23Dr.PulmRoch, maya_sedona, stefan_berlin
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KetoKyle
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678
3,456
Jul 2024
Utah
Mar 10, 2026 at 7:53 AM#3
BethLabQueen said:
Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 40% to 22%.

Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction than glucose or A1C.

My fasting insulin: 23 → 13 → 6 uIU/mL over 9 months. Target is <7. By the time your fasting glucose is elevated, your insulin has been elevated for YEARS trying to compensate.

Ask your doctor to include fasting insulin in your bloodwork panel. It's cheap (~$20) and incredibly informative.

Last edited: Mar 10, 2026 at 8:53 AM
2 22pat_auckland, Dr.GastroMayo
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tom_AK
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Jan 2026
Anchorage, AK
Mar 10, 2026 at 8:12 AM#4
carlos_SATX said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

Adding a me-too, because a thread of one person's experience is not much use. Nothing to add that would improve it.

1 21jennifer_SEA
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Dr.SurgeonPGH
Senior Member
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Mar 2024
Pittsburgh, PA
Mar 10, 2026 at 9:53 AM#5

Clinical perspective, offered as context rather than as advice.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1251078985
Insulin (fasting)211595
HOMA-IR5.53.11.71.4
Uric Acid7.86.55.65.1

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

50 20B12Beth, RickReta_CO, PharmHunterJen and 47 others
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