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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — need advice Page 6

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — need advice

GenomicsKate Sat, Jan 3, 2026 at 11:59 AM 29 replies 1,587 viewsPage 6 of 6
JenMemphis
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Jan 2025
Memphis, TN
Feb 9, 2026 at 9:21 AM#26
hank_denver said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

25 23MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 22 others
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wendy_avl
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245
1,123
Oct 2024
Asheville, NC
Feb 13, 2026 at 10:20 PM#27
hank_denver said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

26 24DoseLogDan, SleepFixSam, PurityPaulOR and 23 others
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steph_laguna
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Nov 2024
Laguna Beach, CA
Feb 18, 2026 at 11:17 AM#28
hank_denver said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

27 0carl_compliance, DanielChem_CHI, marco_milano and 24 others
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traveltech_sara
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678
Jan 2025
Remote, USA
Feb 23, 2026 at 12:11 AM#29

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

28 1NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 25 others
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GenomicsKate
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Oct 2024
Cambridge, MA
Feb 27, 2026 at 1:02 PM#30

Closing the loop on my own question.

For the archive: it took about six weeks rather than the two I expected, and the difference between those two numbers was the whole of my problem.

50 23claudia_zurich, nancy_portland, rick_sfbay and 47 others
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