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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOff-TopicI fit into my college jeans and I am not okay (happy tears) Page 3

I fit into my college jeans and I am not okay (happy tears)

JenMemphis Mon, Apr 13, 2026 at 7:00 AM 27 replies 986 viewsPage 3 of 6
Dr.GutHealth
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Apr 15, 2026 at 6:34 PM#11
Dr.ReproEndo said:
Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.

The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related hospitalizations in GLP-1 agonist users[1].

The mechanism is plausible: GLP-1R is expressed in the mesolimbic reward pathway (VTA, nucleus accumbens). Agonism at these receptors may reduce the reinforcing properties of alcohol, similar to the reduction in "food noise."

RCTs for GLP-1 agonists in AUD are now underway. If positive, this would be a paradigm-shifting repurposing of existing medications.

References:
[1] Wang W, et al. Nat Med. 2024;30:574-584.
17 15VanRx_Mike, steve_okc, dave_SLC and 14 others
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fiona_VT
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Apr 16, 2026 at 1:55 AM#12
pam_columbus said:
Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.

18 16hans_munich, jason_sac26, chris_chi24 and 15 others
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Dr.CardioMD
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Apr 16, 2026 at 9:16 AM#13
Dr.ReproEndo said:
Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

19 17tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 16 others
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TirzTom
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Apr 16, 2026 at 4:37 PM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

20 18SandraNC_45, Dr.EndoIndy, tom_AK and 17 others
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Admin
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Apr 16, 2026 at 11:57 PM#15

Moderator note: a couple of off-topic posts removed.

21 19PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 18 others
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